Fatty Diet Linked to Infertility
In mice, a high-fat diet damages eggs in the ovaries and prevents them from becoming healthy embryos, a finding that may help explain infertility problems in obese women, say researchers at the University of Adelaide in Australia.
They discovered that the main cause of diet-induced infertility in mice is a protein called peroxisome proliferator-activated gamma — found in cells that nourish eggs, Agence France-Presse reported.
“The behavior of this protein helps to determine the way in which the ovaries sense and respond to fats,” said researcher Cadence Minge. “Being able to control this protein will be very important in the quest to reverse fertility caused by poor diets.”
She and her colleagues found that the anti-diabetes drug rosglitazone helped counter the effects of this protein in mice, resulting in better rates of fetal survival and higher birth weights. However, due to potential side effects, this drug can’t be used as a “quick fix” for infertile obese women, AFP reported.
Weight loss is the most effective way for obese women to restore fertility, Minge said.